Allostery : methods and protocols /

Other Authors: Fenton, Aron W.
Format: Book
Language: English
Published: New York : Humana Press : 2011
Series: Methods in molecular biology (Clifton, N.J.) ; v. 796.
Springer protocols (Series)
Subjects:
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245 0 0 |a Allostery :  |b methods and protocols /  |c edited by Aron W. Fenton. 
260 |a New York :  |b Humana Press :  |b Springer,  |c Ã2011. 
300 |a xviii, 439 pages :  |b illustrations (some color). 
336 |a text  |b txt  |2 rdacontent 
337 |a unmediated  |b n  |2 rdamedia 
338 |a volume  |b nc  |2 rdacarrier 
490 1 |a Methods in molecular biology,  |x 1064-3745 ;  |v v. 796 
490 1 |a Springer protocols 
504 |a Includes bibliographical references and index. 
505 0 |a Binding techniques to study the allosteric energy cycle -- Kinetic trapping of a key hemoglobin intermediate -- Allosteric coupling between transition metal-binding sites in homooligomeric metal sensor proteins -- Studying the allosteric energy cycle by isothermal titration calorimetry -- Detecting "Silent" Allosteric coupling -- Using mutant cycle analysis to elucidate long-range functional coupling in allosteric receptors -- A review of methods used for identifying structural changes in a large protein complex -- Allosteric mechanisms of g protein-coupled receptor signaling: A structural perspective -- Dynamic light scattering to study allosteric regulation -- Dissecting the linkage between transcription factor self-assembly and site-specific DNA binding: The role of the analytical ultracentrifuge -- Fluorescence correlation spectroscopy and allostery: The case of GroEL -- The morpheein model of allostery: Evaluating proteins as potential morpheeins -- Combining NMR and molecular dynamics studies for insights into the allostery of small GTPase-protein interactions -- Hydrogen-deuterium exchange study of an allosteric energy cycle -- Ensemble properties of network rigidity reveal allosteric mechanisms -- An in vivo approach to isolating allosteric pathways using hybrid multimeric proteins -- Mutations in the GABA(A) receptor that mimic the allosteric ligand etomidate -- Allosteric regulation of human liver pyruvate kinase by peptides that mimic the phosphorylated/dephosphorylated N-terminus -- In silico-screening approaches for lead generation: Identification of novel allosteric modulators of human-erythrocyte pyruvate kinase -- Identification of allosteric-activating drug leads for human liver pyruvate kinase -- A critical evaluation of correlated mutation algorithms and coevolution within allosteric mechanisms -- The advantage of global fitting of data involving complex linked reactions -- Predicting binding sites by analyzing allosteric effects. 
590 |a Promotion and Tenured Honorees Significant Book 2017 
590 |a Aron Fenton, Ph.D. Professor with Tenure Biochemistry and Molecular Biology 
650 1 2 |a Allosteric Regulation. 
700 1 |a Fenton, Aron W. 
830 0 |a Methods in molecular biology (Clifton, N.J.) ;  |v v. 796.  |x 1064-3745 
830 0 |a Springer protocols (Series) 
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