Statistics applied to clinical trials /

Other Authors: Cleophas, Ton J. M.
Format: Book
Language: English
Published: [Dordrecht] : Springer, 2009
Edition: 4th ed.
Subjects:
Tags: Add Tag
No Tags, Be the first to tag this record!
LEADER 03716cam a2200433 a 4500
001 138467
005 20101117101458.0
008 081020s2009 ne a b 001 0 eng
010 |a  2008939866 
035 |a (OCoLC)ocn305178185 
040 |a UKM  |c UKM  |d DLC  |d COU  |d EMM  |d YDXCP  |d UKMGB  |d KWM 
015 |a GBA915874  |2 bnb 
016 7 |a 014904463  |2 Uk 
019 |a 301783411 
020 |a 9781402095221 (hbk. : alk. paper) 
020 |a 1402095228 (hbk. : alk. paper) 
029 1 |a NLGGC  |b 317206192 
029 1 |a AU@  |b 000043943083 
035 |a (OCoLC)305178185  |z (OCoLC)301783411 
042 |a lccopycat 
050 0 0 |a RM301.27  |b .C5635 2009 
060 4 |a QV 771  |b C628s 2009 
082 0 4 |a 615.507240727  |2 22 
049 |a KWMA 
245 0 0 |a Statistics applied to clinical trials /  |c by Ton J. Cleophas ... [et al.]. 
250 |a 4th ed. 
260 |a [Dordrecht] :  |b Springer,  |c c2009. 
300 |a xxi, 559 p. :  |b ill. ;  |c 25 cm. 
504 |a Includes bibliographical references and index. 
505 0 |a Hypotheses, data, stratification -- The analysis of efficacy data -- The analysis of safety data -- Log likelihood ratio tests for safety data analysis -- Equivalence testing -- Statistical power and sample size -- Interim analyses -- Controlling the risk of false positive clinical trials -- Multiple statistical inferences -- The interpretation of the p-values -- Research data closer to expectation than compatible with random sampling -- Statistical tables for testing data closer to expectation than compatible with random sampling -- Principles of linear regression -- Subgroup analysis using multiple linear regression: confounding, interaction, synergism -- Curvilinear regression -- Logistic and Cox regression, Markow models, Laplace transformations -- Regression modeling for improved precision -- Regression modeling for improved precision -- Post-hoc analyses in clinical trials, a case for logistic regression analysis -- Confounding -- Interaction -- Meta-analysis, basic approach -- Meta-analysis, review and update of methodologies -- Crossover studies with continuous variables -- Crossover studies with binary responses -- Cross-over trials should not be used to test treatments with different chemical class -- Quality-of-life assessments in clinical trials -- Statistical analysis of genetic data -- Relationship among statistical distributions -- Testing clinical trials for randomness -- Clinical trials do not use random samples anymore -- Clinical data where variability is more important than averages -- Testing reproducibility -- Validating qualitative diagnostic tests -- Uncertainty of qualitative diagnostic tests -- Meta-analysis of diagnostic accuracy studies -- Validating quantitative diagnostic tests -- Summary of validation procedures for diagnostic tests -- Validating surrogate endpoints of clinical trials -- Methods for repeated measures analysis -- Advanced analysis of variance, random effects and mixed effects models -- Monte Carlo methods -- Physicians' daily life and the scientific method -- Clinical trials: superiority-testing -- Trend-testing -- Odds ratios and multiple regression models, why and how to use them -- Statistics is no "bloodless" algebra -- Bias due to conflicts of interests, some guidelines. 
650 0 |a Drugs  |x Testing  |x Statistical methods. 
650 0 |a Clinical trials  |x Statistical methods. 
650 2 |a Clinical Trials as Topic  |x methods. 
650 2 |a Data Interpretation, Statistical. 
700 1 |a Cleophas, Ton J. M. 
852 2 |b far.stx  |h QV 771  |i C628s 2009  |t Copy 1 
938 |a YBP Library Services  |b YANK  |n 2950956 
994 |a C0  |b KWM 
999 |a M137156  |d nocirc  |e QV 771 C628s 2009  |m Farha Stacks (Wichita)  |p Farha Only